A0638
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A0638
Sigma
Adipic acid dihydrazide
≥98%
| CAS Number: | 1071-93-8 |
| Linear Formula: | NH2NHCO(CH2)4CONHNH2 |
| Molecular Weight: | 174.20 |
| Beilstein Registry Number: | 973863 |
| EC Number: | 213-999-5 |
| MDL number: | MFCD00007614 |
| PubChem Substance ID: | 24890442 |
Description
| Application | Homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. Typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines. |
| Other Notes | Note that the hydrazone bond may be stabilized by selective reduction using, for example, sodium cyanoborohydride. |
Properties
| assay | ≥98% |
| EQP level | Premium |
| mp | 180-182 °C(lit.) |
| solubility | H2O: 100 mg/mL |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| Flash Point(F) | 302 °F |
| Flash Point(C) | 150 °C |
References
| reference | Heimgartner U, et al., Reversible and irreversible cross-linking of immunoglobulin heavy chains through their carbohydrate residues. Biochem. J. 267, 585-591, (1990) Abstract |
| Beilstein | Beil. 2,IV,1977 |
| FT-IR 2 (1), 1297:B / FT-IR 1 (1), 770:C / IR-Spectra (3), 450:D / RegBook 1 (1), 903:L / Sax 6, 143 / Sigma FT-IR 1 (2), 248:B / Structure Index 1, 139:C:2 |
